Title : Exploring the role and mechanisms of lactiplantibacillus plantarum FRT4 in alleviating obesity and lipid metabolism disorders: Insights from gut microbiota modulation and beyond
Abstract:
Obesity and abnormal lipid metabolism have significant impacts on the health of both humans and animals. Lactic acid bacteria (LAB) have shown potential in alleviating obesity and lipid metabolism disorders. Our research has focused on the effects of specific strains, including Lactiplantibacillus plantarum, Lactobacillus casei, Pediococcus acidilactici, and Enterococcus faecalis. In a high-fat diet (HFD)-induced obese mouse model, intervention with Lp. plantarum FRT4 alleviated obesity and lipid metabolism disorders by modulating the gut microbiota. Similarly, in a fatty liver hemorrhagic syndrome (FLHS) model in laying hens induced by a high-energy low-protein diet, Lp. plantarum FRT4 intervention regulated the gut microbiota, alleviated FLHS, enhanced liver function, and improved egg production. Interestingly, heat-inactivated Lp. plantarum FRT4 also modulated the gut microbiota and alleviated HFD-induced obesity and lipid metabolism disorders, with the inactivated strain showing superior effects compared to the live strain. Furthermore, we extracted and characterized the capsular polysaccharide of Lp. plantarum FRT4. Using HFD-induced obese mouse models and fecal microbiota transplantation, we found that the capsular polysaccharide alleviated obesity and lipid metabolism disorders by modulating gut microbiota-mediated amino acid metabolism. Additionally, both live and inactivated Lp. plantarum FRT4 alleviated depression-like behaviors in mice by regulating gut microbiota-mediated tryptophan metabolism. These findings highlight the potential of Lp. plantarum FRT4 and its derivatives in managing obesity, lipid metabolism disorders, and related behavioral issues through gut microbiota modulation.
