Title : Insights into the health-benefits of protein/peptides of royal jelly and honey
Abstract:
Royal jelly (RJ) is a secretion of the hypopharyngeal and mandibular glands of young worker honeybees 5-15 days old. Larvae designated to be queens are lavishly fed RJ their entire lives, while all other larvae are disconnected from RJ and are provided a bee-bread three days after hatching. Major royal jelly proteins (MRJPs) also familiar as “apalbumins” are among the main components of the RJ. Some research revealed that honeybee genome encodes nine MRJPs (MRJP1-MRJP9). Furthermore, honey bees do actively add MRJPs during, honey processing and ripening thus MRJPs are also found in the honey. MRJP1 is the most abundant and usually found in the oligomeric form known as “apisin” which is association of the 55 kDa monomers “royalactin” with “apisimin” and 24-methylenecholestrol. The biological functions of MRJPs remain unclear with exception of the roles of MRJP1 and its derived peptides known as “jelleins.” The most important biological activities of MRJP1 are antioxidant, antimicrobial, anti-cancer, hypotension, hypolipidemia, hypoglycemia and stimulation of cell proliferation, wound healing, anti-aging, neuroprotective role, and anti-inflammatory and immunomodulatory effects. In addition to the known role of MRJP3 in binding and stabilizing RNA and anti-allergic. Alongside with these functions a glycoprotein that containing three antimicrobial peptides: jelleins 1, 2, and 4 was isolated from natural honey. These peptides were found to cause cell-wall lysis for both Gram-positive and Gram-negative bacteria. Even though RJ has been discovered earlier, research on it started comparatively late compared with the honey. Therefore, this presentation hints insights to trigger researcher’s attentions to towards a perfect food that carries a lot of health-benefits.
Keywords: MRJPs, Royalactin, Functional food, Peptides
Audience take away:
- The audience will get information of this presentation to pick some research problems for their future projects.
- These projects will enhance their careers and jobs.
- Faculty staff could gain new interventions to be used to expand their research networks or teaching programs.
