Title : The antioxidant and analgesic effect of red and white ginseng on Wistar rats
Abstract:
Ginseng is a perennial herbaceous plant from the Araliaceae family which belongs to the genus Panax, especially cultivated in Korea, ginseng is recognized for its general tonic effect, useful for invigorating the body of tired or weakened people, in particular due to its anti-inflammatory and antioxidant effects.
The present work is conducted to assess the importance of panax ginseng by evaluating its use in a targeted population, then determining the pharmacological and therapeutic properties of panax ginseng to study the antioxidant activity of ginseng and its impact on analgesic activity in male Wistar rats.
First, information on the nutritional, therapeutic and cosmetic uses of ginseng was collected from 66 questionnaires. The second step is to evaluate the biochemical potential of the hydro-ethanolic extract of red ginseng and the aqueous extract of white ginseng in vitro and their impact on the antioxidant activity by the DPPH method, then the evaluation of the effect of two variations of panax ginseng on peripheral analgesic activity in male Wistar rats that were injected with acetic acid to induce abdominal pain.
The investigation proved on the one hand, that ginseng is used as a treatment against: Depression, cardiovascular diseases and Diabetes.The antioxidant activity of the extract, by the DPPH method, showed that the red extract tested has a very high antioxidant potential, with an IC50 of 0.75 mg/ml. Comparison of white extract (IC50 of 6.03 mg/ml). The extract revealed a remarkable peripheral analgesic effect, Red Ginseng studied reduced the number of writhing from (46.7±10.0) to (12.3±5.0) with an inhibition rate of 73.66%. In addition, about the White Ginseng extract which has an inhibition rate of 66.8% with number of contortions (15.5±6.6).
To conclude, we can say that there is a significant difference between red and white panax ginseng, moreover it is mainly used for therapeutic purposes. Although the benefits of this product are well known, it is not yet widely used. The biochemical potential, without toxic effect, shows a good content in phenolic compounds due to the variability of these botanical origins which explains its considerable antioxidant capacity.
